The rationale for repurposing cidofovir to selectively target HPV positive and negative epithelial neoplasias KU Leuven
Human papillomaviruses (HPVs) are double-stranded DNA viruses of which the mucosal alpha-types can induce benign (low-risk HPV types) and malignant (high-risk HPV types) lesions. High-risk HPVs are associated with cervical cancer, other anogenital cancers and a substantial amount of head and neck squamous cell carcinoma (HNSCC). Effective prophylactic vaccines are available but are mostly administered to young women and older women and men ...