Projects
Creation of a 3D CRiMe scene to unravel Cytotoxicity Resistant Mechanisms in non-small cell lung cancer. Vrije Universiteit Brussel
CTL-killing resistant mechanisms (CRMs) should be ...
Regulation and significance of natural killer cell mediated cytotoxicity in renal allograft rejection. KU Leuven
Despite the development of potent immunosuppressive therapy, rejection remains the most frequent cause of premature graft loss after kidney transplantation, highlighting the need to better understand the underlying mechanisms. The current paradigm of kidney transplant rejection distinguishes between T-cell mediated rejection (TCMR), referring to tubulointerstitial inflammation caused by alloreactive T lymphocytes, and antibody-mediated ...
Development and validation of a humanized Schizosaccharomyces pombe yeast model for the study of tau-mediated cytotoxicity. KU Leuven
In this research project the use of a new complementairy humanised yeast model to study the fundamental aspect of Tau pathology, will be introduced; the fission yeast Schizosaccharomyces pombe. Tau toxicity is crucial in the development of a certain class of neurodegenerative diseases, the tauopathies, of which Alzheimer's disease is an important example. The main reason for the choice of this new yeast model is the fact the preliminary ...
The impact of lactose-intolerance on gut health: evaluation of the colonic microbiota, fermentation, fecal water genotoxicity and cytotoxicity. KU Leuven
Vesicular recycling from the plasma membrane and disturbance of Ca2+ homeostase as determinants for alpha-synuclein induced cytotoxicity. KU Leuven
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the Western world. Early studies mainly focused on the involvement of environmental factors in the development of PD. More recently, evidence is increasing that genetic factors also play a major role. The first gene identified to be associated with PD encodes for α-synuclein, an unfolded protein of 140 amino acids that is ubiquitously present in the brain. In ...
Helicobacter suis virulence factors associated with cytotoxicity, inhibition of T-cell proliferation and gastric pathology Ghent University
The role of H. suis gamma-glutamyl transpeptidase in gastric epithelial cell death, inhibition of T-cell proliferation and induction of gastric pathology will be studied. Other virulence mechanisms involved in death of host cells will also be identified.