Projects
Rational design and synthesis of antagonists of the TSLP complex using chemo- and bioinformatics approaches. University of Antwerp
Validation of a preclinical model for breast cancer metastasis and identification of targets for immunotherapy. University of Antwerp
Characterization of the cellular and molecular mechanisms leading to the development inflammation-driven immunopathologies in African Trypanosome infection. Vrije Universiteit Brussel
Therefore, the objectives of this proposal fit completely with ...
Advanced T-cell Therapy for Augmented Cancer Killing ("ATTACK"): next-generation T-cell immunotherapy directed against lymphoid malignancies Vrije Universiteit Brussel
Monocyte-derived macrophages as crucial players in the resolution of flammation and tissue repair in Inflammatory Bowel Disease KU Leuven
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract leading to debilitating symptoms such as bloody diarrhea, fatigue and weight loss. To date, no efficient therapies are available for IBD, resulting into an invaluable impact on the emotional, financial and social state of the patients and their families. Although over the last few decades most of the studies on IBD have looked into abnormal ...
Somatic ribosome defects as target for cancer therapy KU Leuven
Mutations in different ribosomal proteins have been described in a series of inherited disorders, known as ribosomopathies. These syndromes come with a variety of symptoms, including hematopoietic defects and a predisposition to develop leukemia and solid tumors later in life. This transition from hypo- to hyperproliferation is a long-standing paradox in the field and the underlying mechanisms by which such ribosomal protein mutations promote ...