Bottom-up manufacturing of artificial anti-tumor T cells KU Leuven
T cells play a central role in anti-tumor immune protection. While their ability to target and eliminate tumor cells is well-recognized, advanced tumors can efficiently evade T cell responses. Significant efforts spanning several decades of research have been made to develop T cell-based therapies manufactured using donor-derived T cells. The use of tumor-directed T cells engineered to express chimeric antigen receptors (CARs) represents, to ...