Projects
Methodological developments for time-resolved single particle cryo-EM Vrije Universiteit Brussel
Deciphering the topology of phosphatidylserine synthesis in the endoplasmic reticulum and its export to acceptor membranes by cryo-EM Vrije Universiteit Brussel
membranes, is linked to a plethora of biological functions. PS
localizes to the cytosolic leaflet of the plasma membrane (PM) but is
absent on the cytosolic face of the endoplasmic reticulum (ER), even
though PS is produced in the ER and distributed from its cytosolic
side to acceptor membranes by non-vesicular transport. Recent data
revealed ...
Molecular mechanism of calcium signaling in muscle contraction Vrije Universiteit Brussel
Structural study and integrative modelling of the yeast Sin3/Rpd3 histone deacetylase complexes KU Leuven
Histone deacetylase (HDAC) enzymes are the main transcriptional repressors in eukaryotes. They do not work in isolation but function within multi-subunit complexes with different associating proteins. Among HDAC machineries, the Sin3 HDAC complex is involved in various cellular processes and diseases. However, the molecular assemblies of Sin3 HDAC complexes remain poorly understood with limited knowledge about how the assembly of the complex ...
Cryo-scanning electron microscope (Cryo-SEM) Ghent University
Materials canU+2019t be observed using SEM without removing water. In contrast, cryo-SEM can be used to study the microstructure of hydrated samples. The goal of cryo-SEM is to vitrify the liquid phase with all the constituents, preserving them in their natural and original state. Cryo-SEM offers an obvious added-value in the visualization of both food products and other biological systems.
Structure and biogenesis of Helicobacter pylori outer membrane proteins Vrije Universiteit Brussel
Bottom-up manufacturing of artificial anti-tumor T cells KU Leuven
T cells play a central role in anti-tumor immune protection. While their ability to target and eliminate tumor cells is well-recognized, advanced tumors can efficiently evade T cell responses. Significant efforts spanning several decades of research have been made to develop T cell-based therapies manufactured using donor-derived T cells. The use of tumor-directed T cells engineered to express chimeric antigen receptors (CARs) represents, to ...
The development and implementation of a COVId-19 scFv-TRAP portfolio for diagnostic and therapeutic applications Ghent University
During the project COVITRAP, we will develop a portfolio of scFv antibodies targeting SARS-CoV-2 spike proteins, a diagnostic tool for virus detection and a scFv-polymer as therapeutics. The antibodies will serve as integral parts of the diagnostic device, where they are immobilized to capture viral particles, and the polymeric inhibitor in which the binding to a virus is realized by the scFvs. All project partners will start the project ...
A broad-spectrum antidote against venomous snakebites based on engineering of nicotinic acetylcholine receptors and derivatives. KU Leuven
Snakebite envenoming affects up to 2.7 million people each year, resulting in 138,000 deaths annually. Consequently, the World Health Organization recently recognized snakebite as a priority Neglected Tropical Disease. Snake venoms are composed of a lethal cocktail of several toxins, including α-neurotoxins that target nicotinic acetylcholine receptors (nAChRs) at the neuromuscular synapse, causing paralysis. Existing snakebite antivenom ...