The role of connexin32 and connexin43 in the control of hepatocellular homeostasis: development of a long-term primary hepatocyte culture system Vrije Universiteit Brussel
Since the liver, and the hepatocyte in particular, plays a key role in generating the pharmaco-toxicological outcome of drugs in the body, primary cultures of hepatocytes are well-acknowledged in vitro tools to investigate potential adverse effects of candidate pharmaceuticals in the early phases of drug development. Their use, however, is mainly restricted to short-term applications, because of the progressive loss of hepatocyte-specific in ...