Projects
Detailed study of protein-protein interactions: study of the activation mechanism of TOLL-like receptors Ghent University
Toll-like receptors are activated by interactions between TIR domeins. Homology models are built for the TIR domains. The MAPPIT method and in vitro binding studies with recombinant TIR domains are combined with extensive mutagenesis studies to identify the interaction interfaces. These data are used as input for data-driven in silico docking. This leads to experimentally validated models for TIR-TIR complexes.
Bioframe, a bioinformatics framework for top down systems biology Ghent University
Systems biology can be defined as the study of biological systems as complex systems arising from interactions between its multiple components. The bioframe project aims at the design of an algorithmic platform for the integration of coupled expression or interaction datasets, pragmatic and useful for the biologist, highly integrated and flexible.
Sensory Integration and Balance Control During Standing and Walking under Challenging Conditions in Healthy Young and Older Adults Hasselt University
Genetic predictors of joint shape and cartilage mechanics Ghent University
Recent genome wide association studies have revealed that several osteoarthritis (OA) risk loci involve common genetic variations related to musculoskeletal development and morphogenesis. To date, a major shortcoming, is that morphometric phenotyping is based on 2D superposition imaging, resulting in high noise levels and limited applicability. In this interdisciplinary project, DNA will be collected from patients undergoing CT scanning for ...
Technology-supported innovative rehabilitation University of Antwerp
Automated VIdeo-based assessment of DYSkinesia in cerebral palsy using markerless pose estimation and machine learning (AVI-DYS) KU Leuven
Movement disorders in dyskinetic cerebral palsy (DCP) are associated with impaired muscle tone regulation and interfere with intentional movements. To treat movement disorders invasive neuromodulation treatments are increasingly applied within DCP. Effective monitoring is extremely important for the indication, evaluation and dosing of these interventions. Current methods to assess movement disorders in DCP are insufficient and ...
Impact of Osteotomy Surgery on Lower-limb Contact Mechanics. University of Antwerp
3D-movement analysis from 2D video; a revolutionary way to assess arm movements during walking without 3D-movement data Hasselt University
MUltiSectoral Integrative approaches to CArdiac care - MUSICARE / Image based patient specific cardiac modeling Ghent University
MUltiSectoral Integrative approaches to CArdiac care – MUSICA - is proposed by a team of universities, companies and hospitals from 4 EU countries (Italy, United Kingdom, The Netherlands, Belgium). The main scope of MUSICA is to structure a new trans-sect