In vitro system for exploring cellular force transmission during angiogenesis. KU Leuven
Organ function is dependent on the formation of a functional blood circulatory network. Angiogenesis is the process of forming new blood capillaries from pre-existing ones, where endothelial cells (ECs) residing on capillary walls invade the surrounding extracellular matrix (ECM) and form angiogenic sprouts. Cell invasion is strongly dependent on the ability of cells to generate traction forces, rendering traction generation fundamental to ...