Projects
TECH-4-kOA -TECHNOLOGY-based GAIT RETRAINING FOR KNEE OSTEOARTHRITIS: Computational modeling- and artificialintelligence-informed, real-life feedback on joint loading. KU Leuven
Osteoarthritis is the most common chronic joint disease, for which no proven prevention or cure exists that reverses or slows down the disease process. Aberrant joint loading accelerates OA progression. Gait-retraining, aiming to restore normal joint loading, therefore, has the potential to slow down OA progression. Previous gait retraining was based on indirect measures of knee joint loading, measured in a lab-based environment. Furthermore, ...
Computational framework for biologically-informed optimization of tissue engineering constructs. KU Leuven
Binnen dit project wordt een computationeel kader tot stand gebracht door het verfijnen van een bioregulatorisch model van botregeneratie met een nauwkeurige beschrijving van de interactie tussen de omgeving van de gastheer en het geïmplanteerde weefselengineering construct. Bovendien wordt een grondige kalibrering en validatie uitgevoerd van in vivo data. Tenslotte wordt dit multischaal computationeel kader gebruikt om biologische ...
Combined experimental and computational analysis of morphogenic processes in the physical framework of the (un)jamming transition KU Leuven
Morphogenic processes during embryonic development are characterised by phenotypical changes that can be interpreted from a physical perspective as phase transitions emerging from interactions between a large number of cells. In particular, the jamming phase transition – a transition form a fluid-like to a solid-like state – was found to control zebrafish anteroposterior (AP) axis elongation. However, the regulation of the jamming transition ...
Hydrodynamic analysis of suction feeding in fishes by means of computational fluid dynamics (CFD). University of Antwerp
Computational methods for modelling the cell cycle as a nonlinear process Ghent University
The aim of this project is the design and development of algorithms for modelling the regulatory cell cycle of plants, in particular Arabidopsis. This is a multidisciplinary project that combines advanced mathematical techniques from dynamical systems theory with computer science methods to study fundamental problems in molecular genetics.
Decision support system for objective nasal airway obstruction assessment using computational fluid dynamics University of Antwerp
Predictive simulations to explore gait control in children with cerebral palsy and provide guidance in the clinical decision making process. KU Leuven
Physics-based simulations of human movement have the potential to predict the functional outcome of treatments, thereby allowing clinicians to personalize and optimize clinical decision-making. These predictive simulations would be particularly valuable for treatments with modest and unpredictable outcomes, such as orthopedic surgeries aiming to improve walking abilities of children with cerebral palsy (CP). Yet computational and modeling ...
4D monitoring of neo-tissue growth inside perfused tissue engineering constructs - A model supported contrast enhanced computed tomography approach. KU Leuven
Tissue engineering (TE) is still facing challenges with respect to the quality of its products. Advancing engineering aspects lacking in the field will be crucial in order to tackle these challenges. Bioreactor technology is one of these enabling technologies that helps to obtain high TE product quality as it allows for controlled in vitro formation of 3D neo-tissues (cells + extracellular matrix). As these neotissue are 3D dynamic structures ...