Projects
Unraveling complex Excited States properties from first-principles (complexES) KU Leuven
"complexES" is a theoretical/ computational chemistry project which
aims to: i) develop, implement and apply theoretical tools enabling
both the accurate and cheap calculation of radiative and nonradiative
excited state (ES) decay rates; ii) developing theoretical descriptors
for the cheap prediction of non-radiative and photochemical reactivity
channels; and iii) the application of the above ...
'Let's keep it complex': Investigating the Effectiveness of Online Learning Environments for Complex Learning through Learning Analytics KU Leuven
According to the European Commission, a challenge in education is to prepare individuals for varied and unpredictable career paths in the future (Rethinking education, 2012). Learning environments should focus on domain-specific and domain-general competencies (e.g., entrepreneurship, foreign language acquisition, and critical thinking) to deal with ill-structured problems in the learning and workplace context. The present PhD project will ...
Analysis of protein/nucleic acid complexes by native ion mobility-mass spectrometry. University of Antwerp
Mechanistic aspects of dehydrogenation reactions on metal-fullerene complexes KU Leuven
The dehydrogenation of water on a Buckminsterfullerene supported vanadium cation has shown a strong involvement of the fullerene support as hydrogen shuttle and as electron sponge. These observations motivate a systematic investigation of dehydrogenation reactions taking place on fullerene supported transition metal atoms and few-atom clusters. In this project, we will study water and ammonia dehydrogenation on neutral and cationic ...
'Take 1' on TAOK2: structural insights into TAOK2 and its complexes with TRIM4 and viral dsRNA Ghent University
Thousand-and-one-amino-acid kinase 2 (TAOK2) is a member of the MAP kinase kinase kinase (MAP3K) family that plays critical roles in various physiological and pathophysiological cellular responses, such as regulation of microtubule dynamics and antiviral immunity. The literature links sensing of dsRNA and activation in innate immunity by TAOK2 to its interaction with the ubiquitin ligase protein TRIM4. However, the structural and mechanistic ...
Characterization of non-canonical EZH2 transcriptional complexes to identify new therapeutic targets in peripheral T cell lymphoma. KU Leuven
Peripheral T cell lymphoma (PTCL) is a form of blood cancer that develops from mature T cells, a type of white blood cells. These T cells are growing uncontrollably, thereby forming a tumor that is mostly located in the lymph nodes. PTCL patients are currently treated with chemotherapy, but the chances of survival are only 30%. Therefore, there is a high clinical need for new therapeutic options for these patients. The behaviour of a cell is ...
TLX transcriptional complexes in T-cell acute lymphoblastic leukemia KU Leuven
TLX1 and TLX3 are related transcription factors that are upregulated by chromosomal translocations in about 35% of T-cell acute lymphoblastic leukemia cases. We have previously shown that TLX1 can cooperate with the oncogenic kinase NUP214-ABL1 to drive leukemia development and we have now demonstrated a similar cooperation between TLX3 and mutant FLT3 kinase. However, it remains unclear how TLX1 and TLX3 deregulate transcription in T-ALL. In ...
Structural study and integrative modelling of the yeast Sin3/Rpd3 histone deacetylase complexes KU Leuven
Histone deacetylase (HDAC) enzymes are the main transcriptional repressors in eukaryotes. They do not work in isolation but function within multi-subunit complexes with different associating proteins. Among HDAC machineries, the Sin3 HDAC complex is involved in various cellular processes and diseases. However, the molecular assemblies of Sin3 HDAC complexes remain poorly understood with limited knowledge about how the assembly of the complex ...