Infrastructure
Astroparticle Physics with the IceCube Neutrino and Cosmic Ray Observatory at the South Pole and a High-Energy Extension of One complete BAS BigRAID system (IceCube) Ghent University
Since the discovery of cosmic rays in 1912, we still do not know what the sources of these charged energetic particles are. Cosmic rays are detected through interactions in the Earth's atmosphere, and to identify the sources, one must determine the composition by measuring the secondary particles produced. However, the discovery of high-energy cosmic neutrinos by IceCube has ushered in a new era called neutrino astronomy and heralded as the "breakthrough of 2013." Neutrinos are excellent astrophysical messengers; they interact only weakly and point back to their source. The sources of ...
HEtrogenous, 3D microsystems processing Line for Complex multidisciplinary device research (LENA CLEAN ROOM) KU Leuven
During the last decades more and more researchers from a wide variety of fields have become interested in investigating very fine structures, having components as small as a millionth of a meter and even below. This started with the advent of microelectronics several decades ago. Now, also biologists, (bio)chemists, physicists and sensor researchers feel the need to work with microtechnology. Thus, it is important that the equipment for fabricating such structures is available to researchers. The main applicants for this project have been building up a microfabrication lab for decades. ...
Nuclear Magnetic Resonance spectrometers (NMR) Ghent University
The NMR Expertise Center (NMR EC) currently (December 2022) has 5 NMR spectrometers of different field strengths going from 300MHz to 700MHz. Each spectrometer is equipped with one or more detection probes that allow to interrogate organic molecules in solution about their molecular structure, behavior in solution, internal dynamics, intermolecular interactions, ... . Examples of these organic molecules include natural and synthesis products, polymers, metabolites, complex peptides, nucleic acids and sugars. Each probe has multiple channels where a diversity of atomic nuclei can be ...
The PaRtiCLE proton center (PARTICLE) KU Leuven
UZ Leuven and its partners are completing the construction of the first Belgian proton therapy center ParTICLe. The proton therapy center benefits from a unique configuration with two independent cyclotrons, one dedicated to the clinic and the other dedicated to research, both of which deliver protons up to 230 MeV, in two separate rooms. Because of its proximity to the MoSAIC, the research beam line could ideally be used to demonstrate specific effects of protons in pre-clinical models, especially those related to high dose rates (FLASH) but also more complex radiological effects such as ...
Mesoscale Ecotrons University of Antwerp
When size matters: a platform to study molecular interactions and multimerisation (SIZEMAT) KU Leuven
A system that offers a choice of resolving the samples according to hydrodynamic volume using either size-exclusion chromatography or field-flow fractionation with an online multi-detector system including multi-angle light scattering, dynamic light scattering, UVvisible light absorption, refractometry, and the detection of fluorescence spectra. The requested instrument allows to separate a complex molecular sample according to the size of the comprising molecules, followed by immediate inline characterisation of the molecular weight, shape,
concentration and binding to ...
A platform for next-generation comprehensive proteome analysis: liquid chromatography trapped-ion-mobility time- of-flight (LC-timsTOF) mass spectrometry (LS-timsTOF) Vrije Universiteit Brussel
combined with specialist expertise, aimed to complement the world-leading genomic life-science research at the VUB to fully characterize complex biological systems with multi- omic data. The LC-MS platform will be optimized towards unprecedented resolving power and ultra-high detection sensitivity for deep ...
Platform for Next Generation Screening in Quantitative Biology & Drug Discovery (NEXTGEBQBIO) KU Leuven
In this proposal we outline a state-of-the-art platform that would be among the first in Europe to combine the best in automated microscopy with advanced cell culture robotics capable of automated isolation, expansion and differentiation of mammalian and human cells, including iPSC. The platform will be unique in Flanders and will allow running quantitative image-based screens as well as screens for disease phenotypes using conventional cell lines but more importantly also on human stem cells, which provide the closest mimic of human pathology currently available. Not only will this prove ...
Imaging the invisible in preclinical models using magnetic particle imaging (MPI Magnetic Particle Imaging) Ghent University
The Magnetic Partcile Imaging (MPI) workflow combines some of the best features of existing medical imaging methods: (1) easy as optical imaging, (2) specific as positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging, (3) fast as computed tomography (CT) imaging, and (4) safe as magnetic resonance imaging (MRI). This will be explored in detail below. MPI has the sensitivity and ease of use of optical imaging. With a nanomolar detection limit, MPI sensitivity can be compared with in vivo fluorescence imaging, but without the confounding tissue ...