Using mucins as friends in colorectal cancer diagnostics and treatment KU Leuven
We showed that half of the colorectal polyps and tumors, termed iCMS3, develop through differentiation of mature colonocytes into gastric-type, metabolically-skewed neoplastic cells. These cells and tumors show overexpression, production and presentation of gastric and colonic type mucins. In these iCMS3 tumors, we observe high T cell infiltration, but these are incompletely reactive and hence incompetent at clearing the tumor.
Moreover, ...