Projects
A controlled phase II clinical trial evaluating efficacy of myelin peptide-loaded tolDC as treatment for MS. University of Antwerp
Multicenter randomized controlled clinical trial comparing ebastine and mebeverine as treatment of irritable bowel syndrome KU Leuven
Innovation / final utilisation goal
To date, treatment of IBS is rather disappointing leading to impaired QoL and high health care costs.
Based on our previous work, we aim to provide further evidence supporting histamine 1 receptor antagonism as a novel approach to treat patients suffering from IBS. We will therefore compare treatment with the histamine 1 receptor antagonist ebastine and the antispasmodic mebeverine, one of the ...
Trp-IBD: Tryptophan for persistent fatigue in quiescent Inflammatory Bowel Disease: a double-blind placebo-controlled clinical trial Ghent University
The end use of this project proposal is to provide evidence for the attribution of a therapeutic property to the dietary supplement tryptophan (Trp) for pathological fatigue in patients with inflammatory bowel disease (IBD) in remission. It offers gastroenterologists and general practitioners the opportunity to treat this persistent complaint in their patient population, through a means that is widely available and safe.
Conversations of terminal status: development of a guidance tool for a clinical intervention trial in oncology Vrije Universiteit Brussel
However, not informing the patient of terminal status often results in futile treatment, overly burdening the patient and making unnecessary costs and use of ...
The added value of a behavioral weight reduction program to current best evidence rehabilitation in patients with chronic low back pain: A randomized clinical trial Vrije Universiteit Brussel
Modern pain neuroscience applied to pain in breast cancer survivors: a randomized clinical trial of pain neuroscience education combined with exercise therapy. Vrije Universiteit Brussel
During survivorship, surveillance for recurrence is a top priority.
However, health caretakers and patients are at risk of neglecting other aspects of their health status such as pain that can have a big impact on the health-related quality of life (HRQoL) and healthcare costs. One out of three breast cancer survivors (BCS) will face pain complaints long after ...
The role of pain cognitions in healthcare utilization in patients undergoing surgery for lumbar radiculopathy: A multicenter randomized controlled clinical trial Vrije Universiteit Brussel
Do the EU and relevant national legal frameworks provide for a fair allocation of data control and responsibility in the context of precision medicine? A case study of clinical trials KU Leuven
Clinical research relies on patient participation and the use and (re-)use of sensitive personal data. Moreover, several types of research are heavily dependent on exchange of data between countries (e.g., precision medicine trials), and all health research would benefit from greater, meaningful cross-border collaborations, as shown during the COVID-19 crisis. However, the current legal system for the conduct of cross-border research in the ...
Peroxisomal biogenesis defects: identification of pharmacological treatments and endpoints in clinical trials. KU Leuven
By means of clinical trials, we want to arrive at the specific identification of pharmacological treatments and the determination of endpoints in the prevention of peroxisomal biogenesis defects.