The replication cycle of HIV is a complicated interplay between viral and cellular proteins. Until now antiretroviral therapy mainly targets the viral proteins although the interaction between the viral and cellular proteins could be interesting new drug targets. This strategy is mainly of interest because cellular proteins are much less prone to mutations which gives the virus less opportunity to develop drug resistance. My laboratory has ...
Exploration of the therapeutic potential of protein phosphatases involved in chromatin signaling. KU Leuven
Optimizing an experimental approach to silence disease-related genes by interfering with their chromatin structure. Epigenetic silencing of the human androgen receptor. KU Leuven
Unraveling the structural/topological aspects and the energetics related to complex DNA or chromatin interactions of high order nucleoprotein complexes involved in HIV/AIDS and/or leukemia. KU Leuven
Effects of Screotal Insulation on Sperm Kinetics, Chromatin Protamination and Gene Expression Pattern in Belgian Bleu and Holstein-Friesian AI Bulls. Ghent University
In this research we will look into transient rises of temperature effects on sperm kinetics, DNA chromatin protamination and gene(s) expression pattern within and among BB and HF bulls and effects of heat- stressed spermatozoa on fertilization and subsequent embryo development in vitro.
Targeting the chromatin-reader function of LEDGF/p75 for the treatment of Mixed-Lineage-Leukemia (TReaT-MLL) KU Leuven
The clarification of biomolecular architecture responsible for disease images and their treatment via optical and non-optical superresolution microscopy and spectroscopy techniques. KU Leuven
A combination of nanoresolution microscopy techniques, such as atomic force microscopy (AFM) Fluorescence Imaging with One Nanometer Accuracy (FIONA) and tip enhanced Raman spectroscopy (TERS), will be used to study the biomolecular interactions of ligands with DNA and the impact of this interaction on the DNA structure. At first the binding of lens epithelium derived growth factor (LEDGF/p75) with chromatine will be studied. The information ...
Genome-wide promotor binding profiling of Protein phosphatase 1 and its major nuclear targeting subunits KU Leuven
Tissue specific modulation of the effects of glucocorticoids by androgens and the androgen receptor: revealing the mechanisms of cross tal KU Leuven
Androgens and glucocorticoids are steroid hormones with very different roles in (patho-)physiology. While androgens are known as the male steroids with anabolic effects, glucocorticoids are catabolic hormones with a key role in metabolic processes that govern whole-body energy metabolism. Clinically, long term use of androgens results in increased bone and muscle formation, while glucocorticoids induce osteoporosis and muscle loss. By ...
ERC Professorship: EPITALL Ghent University
Dynamic interplay between histone modifications and DNA methylation defines the chromatin structure of the genome and serves as a conceptual framework to understand transcriptional regulation in normal development and disease. The goal of this research proposal is to study the chromatin architecture during normal and malignant T cell differentiation in order to define how DNA methylation drives oncogenic gene expression.