Projects
Study the efficacy and mechanism of targeted TIM3 and VISTA in the treatment of gastroesophageal junction / gastric cancer patients with low immunogenicity and FLOT chemotherapy resistance KU Leuven
Antibody-based immune checkpoint (IC)-blockers (ICBs) have revolutionized clinical cancer immunotherapy, but applied as monotherapy, only a subset of the patients respond to ICBs targeting CTLA4/PD(L)1. Combinatorial application of ICBs with cytotoxic therapies like chemotherapy can extend these remarkable responses to non-responders. Currently this strategy is not entirely accounting for the potential ‘skewing’ effects of dying cancer cells, ...
Combined chemotherapy and inflammasome neutralization for the treatment of non-small cell lung carcinoma Ghent University
Chemoresistance of non-small-cell lung carcinoma (NSCLC) cells underlies the poor prognosis of patients with advanced disease. Hence, it seems plausible to combine the standard-of-care chemotherapy for NSCLC (typically a combination of platinum-based compounds and taxanes) with strategies that block the induction of chemoresistance.
Recent evidence illustrated that tumor-associated macrophages contribute to diminished therapy ...
Impact of prenatal exposure to cancer treatment during pregnancy and of chemotherapy for breast cancer on the brains: a multimodal MR imaging study KU Leuven
In the first part of this project we will analyse data from a longitudinal study where we followed 80 patients with breast cancer from diagnosis until a year after treatment, using MRI of the brains, neuropsychological testing and blood samples. After chemotherapy, many patients experience cognitive complaints. Moreover, using MRI, we previously showed that there are structural and functional changes in the brain. However, the link between ...
Unravelling the synergistic potential of CD70directed CAR natural killer cells with firstline chemotherapy in 3D culture models as a novel combination treatment for metastatic colorectal cancer patients. University of Antwerp
Pharmacologic modulation and standardization of intraperitoneal chemotherapy in peritoneal carcinomatosis treatment. Hasselt University
Improving frontline treatment for malignant pleural mesothelioma with concomitant platinum/pemetrexed-based chemotherapy and Wilms' tumor protein 1 (WT1)-targeted dendritic cell immunotherapy. University of Antwerp
Development of cost-effective tools to optimize treatment and monitoring of drug efficacy resistance in chemotherapy programmes against soil-transmitted helminths. Ghent University
Cost-effective tools to guide health care decision makers on how to optimize treatment strategies to control soil-transmitted helminthes (STH) and on how to detect development of anthelmintic resistance (AR) are not yet available in public health. Our main objective is to improve the current control of STH through the development of cost-effective tools to optimize PCT and to detect development of AR.