Combined chemotherapy and inflammasome neutralization for the treatment of non-small cell lung carcinoma Ghent University
Chemoresistance of non-small-cell lung carcinoma (NSCLC) cells underlies the poor prognosis of patients with advanced disease. Hence, it seems plausible to combine the standard-of-care chemotherapy for NSCLC (typically a combination of platinum-based compounds and taxanes) with strategies that block the induction of chemoresistance.
Recent evidence illustrated that tumor-associated macrophages contribute to diminished therapy ...
Pharmacologic modulation and standardization of intraperitoneal chemotherapy in peritoneal carcinomatosis treatment. Hasselt University
Improving frontline treatment for malignant pleural mesothelioma with concomitant platinum/pemetrexed-based chemotherapy and Wilms' tumor protein 1 (WT1)-targeted dendritic cell immunotherapy. University of Antwerp
Development of cost-effective tools to optimize treatment and monitoring of drug efficacy resistance in chemotherapy programmes against soil-transmitted helminths. Ghent University
Cost-effective tools to guide health care decision makers on how to optimize treatment strategies to control soil-transmitted helminthes (STH) and on how to detect development of anthelmintic resistance (AR) are not yet available in public health. Our main objective is to improve the current control of STH through the development of cost-effective tools to optimize PCT and to detect development of AR.
Investigation of non-thermal plasma therapy with first-line treatments of recurrent and metastatic head and neck squamous cell carcinoma: a novel combination with platinum-based chemotherapy and immunotherapy. University of Antwerp
Impact of a mindfulness-based intervention on cognitive functioning and recovery of brain changes after chemotherapy KU Leuven
The survival rate of cancer patients has increased significantly because of earlier diagnosis and improved cancer treatments. As a result, the quality of life after cancer treatment is receiving more and more attention in recent years. In particular the prevalence of cognitive complaints in cancer patients has become an important area of research. Cognitive changes associated with treatments for central nervous system (CNS) malignancies have ...
Acute lymphoblastic leukemia (ALL) is an aggressive leukemia that is most common in children and adolescents. Longterm ALL survival rates have significantly improved by the use of intensified chemotherapy and reach 80% in pediatric cases, and 60% in adult ALL, but are associated with substantial acute and long-term side effects. Moreover, the outcome of ALL patients with primary resistant or relapsed disease remains extremely poor en ...
Towards a PD biomarker guided therapy for patients with peritonealcarcinomatosis: combining patient-derived xenograft models andtranslational PKPD modeling to pave the way for a new paradigm inintraperitoneal chemotherapy Ghent University
Nowadays, patients with tumor metastases in the abdominal cavity are treated, with chemotherapy applied directly in the abdominal cavity, without the proper tools for a physician to follow up on the treatment. This in combination with the current uncertainties with regards to the optimal amount of drug to use and the optimal treatment duration make that, in our opinion, much room is left for improvement of the current implemented ...
Impact of vaginal morbidity on sexual functioning in cervical cancer patients treated with neo-adjuvant chemotherapy followed by surgery. Ghent University
In Belgium, 600 women are yearly diagnosed with cervical cancer
(CX), with a peak around 45 years (sexually active at the time of
diagnosis). Treatment of limited CX consists of surgery, completed
by chemo-radiotherapy (C-RT) in case of high-risk of relapse.
Inoperable, locally advanced tumors are treated by C-RT and
brachytherapy. The 3-year local control is 73% to 94%. To increase
this, we have been treating ...