Laboratory of Metabolic Regulation of Cell Function KU Leuven
Metabolic Regulation of Cell Function
Metabolic Regulation of Cell Function
research
1. Pluripotent Stem Cells and Reprogramming
2. Pluripotent Stem Cell Differentiation
3. Adult Stem Cells
4. Disease Modelling and Regenerative Therapies
The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related ...
The primary objectives of the lab are 1) to understand the role of peroxisomes and in particular of peroxisomal β-oxidation in diverse tissues and during different stages of life 2) to investigate the pathological mechanisms in peroxisomal diseases which should allow the development of therapies. To approach these questions we generated a series of mouse models with global or cell type selective inactivation of functional peroxisomes or of ...
The research interests from the Laboratory for Mechanisms of Cell Transformation are focused on understanding the cooperative interactions that conspire to promote tumorigenic transformation. To discover drivers of cancer development and progression, they create experimental models of cell transformation derived from primary human cells that mimic alterations found in human cancer samples. These models provide a useful platform to delineate ...
Using a large panel of classical morphological techniques incl. enzyme- andimmunohistochemistry, as well as more advanced molecular techniques on tissue sections, we investigate the histology & the function of a variety of human tissues in normal & in pathological conditions.Throughout these research activities we attempt to optimise the available morphological techniques for light microscopy, electron microscopy, incl. transmission ...
We want to force a breakthrough in the cure of neuronal and neurodegenerative disorders. This requires a deep understanding of normal brain function and translation of this knowledge into a solid mechanistic understanding of disease mechanisms.
The main research topics of ECMR are the investigation of liver cell biology and the more applied research line of drug design.