Circulating cell-free DNA: a novel gateway to the genome of Hodgkin/Reed-Sternberg cells in Hodgkin Lymphoma? KU Leuven
Hodgkin lymphoma (HL) accounts for 11-30 % of all lymphomas and is the most common lymphoid neoplasm in adolescents. Today, 10-15% of patients fail first-line therapy – others risk of being overtreated, underscoring the need to better recognize HL diversity.
Given the technical challenge of purifying the low abundant, malignant Hodgkin/Reed-Sternberg (HRS) cells from biopsies, this study aims to explore the genome of HRS cells by ...