Dissecting stromal-cancer cell interactions at the perivascular niche to detect and intercept the early metastatic process. Ghent University
Metastasis formation is the primary cause of cancer-related deaths. Preliminary data from our consortium identifies the perivascular niche as a hub of complex and dynamic cellular interactions and a source of microenvironmental secreted factors that promote primary tumor growth, early metastatic dissemination, and outgrowth at distant organs. We now aim to understand how the various stromal and immune cell types/states residing in this ...