Publications
Immunogenicity of human embryonic stem cell-derived beta cells Vrije Universiteit Brussel
AIMS/HYPOTHESIS: To overcome the donor shortage in the treatment of advanced type 1 diabetes by islet transplantation, human embryonic stem cells (hESCs) show great potential as an unlimited alternative source of beta cells. hESCs may have immune privileged properties and it is important to determine whether these properties are preserved in hESC-derived cells.
METHODS: We comprehensively investigated interactions of both innate and ...
Boost for Alginate Encapsulation in Beta Cell Transplantation Vrije Universiteit Brussel
A recent study reported that encapsulation of human embryonic stem cell (hESC)-derived beta cells by a novel alginate formula protects against foreign body reactivity in immune-competent mice. Intraperitoneal implants corrected a diabetic state for at least 6 months. These observations will stimulate the development of alginate encapsulation towards novel cell therapy protocols for treating type 1 diabetes (T1DM).
Assessment of functional beta cell mass in macro-encapsulated stem cell-generated implants Vrije Universiteit Brussel
Functional beta cell mass from device-encapsulated hESC-derived pancreatic endoderm achieving metabolic control Vrije Universiteit Brussel
Human stem cells represent a potential source for implants that replace the depleted functional beta cell mass (FBM) in diabetes patients. Human embryonic stem cell-derived pancreatic endoderm (hES-PE) can generate implants with glucose-responsive beta cells capable of reducing hyperglycemia in mice. This study with device-encapsulated hES-PE (4 × 10 6 cells/mouse) determines the biologic characteristics at which implants establish metabolic ...
Cell Mass Increase Associated with Formation of Glucose-Controlling beta-Cell Mass in Device-Encapsulated Implants of hiPS-Derived Pancreatic Endoderm Vrije Universiteit Brussel
Device-encapsulated human stem cell-derived pancreatic endoderm (PE) can generate functional β-cell implants in the subcutis of mice, which has led to the start of clinical studies in type 1 diabetes. Assessment of the formed functional β-cell mass (FBM) and its correlation with in vivo metabolic markers can guide clinical translation. We recently reported ex vivo characteristics of device-encapsulated human embryonic stem cell-derived ...