Glucose-induced cell signaling in pancreatic ß cells during pregnancy: mechanisms of adaptation and implication for gestational diabetes KU Leuven
Glucose homeostasis in the body is determined by insulin secretion by pancreatic ß cells and glucose uptake in response to insulin. Pregnancy is a profound challenge for glucose homeostasis of the female body. Though a large amount of data indicates that pregnancy hormones change properties and gene expression of insulin secreting pancreatic ß cells, hardly any data describes the adaptations in glucose induced cell signalling in the ß cell ...