Barriers and carriers for non-viral delivery of mRNA to induce transient protein expression in the retina: the hurdles of the inner limiting membrane and innate immunity versus the potential of mRNA self-amplification. Ghent University
Vision loss has a huge impact on patients and their environment. The causes of vision loss often lie in abnormalities in the genetic material of cells in the retina. Messenger RNA (mRNA) administration to the retina has the potential to correct these genetic abnormalities and thus reduce or even reverse the loss of vision. To deliver the mRNA, it is packaged in a nanoparticle that helps the mRNA to reach its target cells. The most safe method ...