Research assignment evolution care landscape Ghent University
geen abstract
This project will invesigate how pyruvate metabolically regulates CP4H metastatic growth. I will address this objectives by studying proline metabolism and its inhibition in 3D cultured breast cancer cells and in a metastatic breast cancer mouse model using metabolmics, imaging and molecular biology techniques.
In this project regulatory modules will be detected in the transcriptome of mouse dendritic cells using biclustering. Expression data from healthy mice as from mice with an induced inflammation will be used. In later stages the regulatory modules will be further refined using data from knock-out mice, cell lines and time-series experiments.