Projects
Exploring molecular mechanisms underlying arrhythmogenic cardiomyopathy using human engineered heart tissue Ghent University
Differences in DNA methylation patterns, distinct from normal age and breed-specific changes, affect the feline hypertrophic cardiomyopathy phenotype. Ghent University
Whole exome sequencing will be used for the first time in cats to identify HCM-causing mutation(s) in British Shorthair cats. Next, DNA methylation patterns will be analyzed to check if specific epigenetic changes are linked to HCM and whether patterns present in blood cells can also be used as biomarker for HCM.
BLOOD PRESSURE INDUCED PREMATURE VENTRICULAR BEATS AS TRIGGERS FOR VENTRICULAR ARRHYTHMIA IN ISCHEMIC CARDIOMYOPATHY KU Leuven
Disturbance of the cytoskeleton-plasmamembrane interactions results in intercalated disc malformation and induces cardiomyopathy Ghent University
Arrhythmogenic Ventricular Cardiomyopathy (AVC) is a genetic, progressive heart condition with abnormal heart rhythm and malfunction of the ventricles. AVC is often caused by mutations in proteins belonging to the areae compositae localized at the intercalated disc. Crucial is the link with the cytoskeleton. This project aims to gain more insights into this link and its contribution to cell-cell interactions and mechanotransduction
The relation of regional myocardial function and metabolism to identify non-invasive parameters for the prediction of disease progressiontherapy success in patients with dilated cardiomyopathy. KU Leuven
Investigating the relation of regional myocardial function and metabolism to identify non-invasive parameters for the prediction of disease progressiontherapy success in patients with dilated cardiomyopathy.
Bone marrow dysfunction and reversibility in patients with ischemic cardiomyopathy. University of Antwerp
High-intensity interval training in diabetic cardiomyopathy: from molecular changes towards clinical benefits Hasselt University
Advanced 3D Complex Tissues BioAssembly Platform for Precision Disease Modeling, Drug Discovery and Regenerative Medicine (3D-BioBOT) KU Leuven
A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cells KU Leuven
Ionized calcium (Ca2+) is the most versatile cellular messenger used by cells. Virtually all cells in the human body employ Ca2+ signals, i.e. rapid changes in intracellular Ca2+ concentration, to control cell physiological functions in response to extrinsic and intrinsic stimuli. Perturbations in Ca2+ homeostasis & dynamics vitiate physiological processes, acting as early drivers of disease progression and pathological outcomes. Hence, ...