Identification of flow-inducible BMP signalling pathways and characterization of their role during embryonic vascular remodelling KU Leuven
The circulatory system is the first organ system to become functional during embryonic development and is required for survival of the embryo. As such, the vasculature must grow with the embryo, be efficient, and perfuse all tissues and organs. In the mouse embryonic yolk sac, the initial vasculature consists of a randomly organized, honeycomb-like network of capillaries. As the heart begins to beat and red blood cells enter circulation, this ...