Projects
New beam forming methodologies for fast transoesophageal volumetric cardiac imaging using ultrasound KU Leuven
As cardiovascular diseases remain the leading cause of death worldwide, the scientific community strives to develop advanced diagnostic tools to detect early cardiac dysfunction. Echocardiography has established itself as a major trump in this quest. Novel treatments have also emerged, offering new hope in combating these pathologies. With them, it came the need for new monitoring tools and there again, ultrasound - and especially, ...
Automated assessment of cardiac morphology and function: An integrated B-spline framework for real-time segmentation and tracking of the left ventricle KU Leuven
With the increasing prevalence of cardiovascular diseases, the need for advanced diagnosis systems that are able to detect early cardiac dysfunction are now needed more than ever. Real-time 3D echocardiography has made its way into clinical practice over the last decade and is now generally accepted as a competitive alternative to cardiac magnetic resonance imaging for volumetric assessment of left ventricular morphology and function. ...
In vivo study of cardiac function and inflammation after ischemia/reperfusion KU Leuven
Risk stratification of sudden cardiac death. KU Leuven
Sudden cardiac death (SCD) is defined as a non-traumatic, fatal event occurring within 1 hour of the onset of symptoms in an apparently healthy subject. The annual incidence varies widely across different studies. In the USA reported incidences varied from 180 000 to over 450 000 cases of SCD nationwide. SCD can present as a ventricular tachyarrhytimia, either ventricular tachycardie (VT), ventricular fibrillation, pulseless electrical ...
Measurement Uncertainty in Digital Twins for Cardiac Electrophysiology KU Leuven
Digital twins are ubiquitous in all kinds of technology development and have the potential to revolutionize medicine and especially cardiac electrophysiology. The electrophysiological behaviour, i.e. the activation of the heart muscle is complex but rather well understood, which makes that it can be modeled with quite a lot of detail. Based on the digital representation of the patient's heart, treatment options for cardiac arrhythmias can be ...
Personalized Cardiac Function Estimation from Volumetric Ultrasound Images KU Leuven
Cardiac arrhythmias are a leading cause of death worldwide. Although different heart rhythm disorders can be recognized using the electrocardiogram, the precise three-dimensional spatiotemporal organization of cardiac activation patterns inside the heart during certain arrhythmia types is not well understood. Commonly, invasive catheter recordings are needed to record electrograms that hint at the location of abnormal sources or re-entrant ...
an in-depth histopathologic assessment of cardiac remodeling KU Leuven
Remodellation of the heart and vascular tissues is an important basic concept in many research projects. The aim of this PhD thesis is to identify the cellular pathways involved in the remodellation process by performing morphological and immunohistochemical tissue examination. Understanding the composition of the inflammatory infiltrate and other cell types and their differentiation, is crucial to predict the result of the process, being ...
Inverse modeling of Cardiac ARrhythmia sources based on UltraSound imaging (ICARUS) KU Leuven
The role of machine perfusion for cardiac transplantation using donors after circulatory death. KU Leuven
Hearts donated after circulatory determination of death are usually preserved with normothermic machine perfusion prior to transplantation. With this type of preservation, the donor heart suffers from warm ischaemia, and correct evaluation of the heart function is not possible. Therefore, the search for other types of preservation started. There is a new possibility of using normothermic regional perfusion combined with cold storage. We would ...