Projects
CONNEXIN-43 HEMICHANNELS AS PRO-ARRHYTHMIC MEDIATORS IN CARDIAC HYPERTROPHY AND HEART FAILURE Ghent University
Connexins are crucial proteins in the heart that facilitate impulse conduction over the cardiac tissue thereby coordinating the atrioventricular contraction cycle in a spatiotemporal manner. Connexins form hemichannels that assemble as gap junctions and directly connect cardiomyocytes as well as cells of specialized conduction tissues. Hemichannels not only combine to form gap junctions but are also present as free membrane channels not being ...
Connexin-43 Hemichannels as pro-arythmic mediators in Cardiac Hypertrophy and Heart Failure KU Leuven
Connexins are crucial proteins in the heart that facilitate impulse conduction over the cardiac tissue thereby coordinating the atrioventricular contraction cycle in a spatiotemporal manner. Connexins form hemichannels that assemble as gap junctions and directly connect cardiomyocytes as well as cells of specialized conduction tissues. Hemichannels not only combine to form gap junctions but are also present as free membrane channels not being ...
Development and validation of a proficiency-based progression simulation training curriculum for novice cardiac device implanters KU Leuven
Cardiac Implantable Electronic Device (CIED) procedural training for novice operators usually happens in-vivo from the very first attempts. Curriculum structure and implant techniques often differ among teaching centres. Competence level is classically associated to number of cases performed and time spent in training. Furthermore, skill assessment relies on supervisors’ individual judgement. Patients should be assured of a verified and ...
Loss of cardiac resident macrophage self-renewal as a trigger for Heart Failure with preserved Ejection Fraction. KU Leuven
Heart Failure with Preserved Ejection Fraction (HFpEF) is a pathology with few current therapeutic options that are further diminished as HFpEF is mostly diagnosed at a late stage. At a cellular level, vascular dysfunction, fibrosis, and an increased inflammatory response are known HFpEF characteristics, but no consensus has been researched concerning underlying mechanisms. The cardioprotective function of resident cardiac macrophages is an ...
The best of both worlds: boosting the potential of CASCs with DPSCs for true cardiac repair. Hasselt University
The best of both worlds: boosting the potential of CASCs with DPSCs for true cardiac repair. Hasselt University
Inherited cardiac arrhythmias: identification of novel genes and development of a new diagnostic tool for translating genetic diagnosis into precision medicine. University of Antwerp
CASC transplantation as a new therapy to restore cardiac function after ischemic heart failure. Hasselt University
New beam forming methodologies for fast transoesophageal volumetric cardiac imaging using ultrasound KU Leuven
As cardiovascular diseases remain the leading cause of death worldwide, the scientific community strives to develop advanced diagnostic tools to detect early cardiac dysfunction. Echocardiography has established itself as a major trump in this quest. Novel treatments have also emerged, offering new hope in combating these pathologies. With them, it came the need for new monitoring tools and there again, ultrasound - and especially, ...