Projects
CASC transplantation as a new therapy to restore cardiac function after ischemic heart failure. Hasselt University
In vivo study of cardiac function and inflammation after ischemia/reperfusion KU Leuven
Estimating regional cardiac function using 3D ultrasound imaging. KU Leuven
Modulation of cardiac myocyte structure and function by different types of fibroblastic cells. KU Leuven
Assessment of cardiac function by new ultrasound imaging strategies: towards a reliable clinicalroutine. KU Leuven
Cardiovascular diseases remain the leading cause of death in the world and has a tremendous impact on our society. Since major diseases are associated with dysfunction of the left ventricle, the accurate assessment of ventricular function during all phases of the heart cycle is fundamental. This goal may be facilitated by ultrasound imaging, which is in general appreciated for its bedside applicability, good temporal resolution, real-time ...
"Epigenetic regulation of cardiac myocyte proliferation/cell cycle – from single cells to organ function." KU Leuven
This Ph.D. project is built upon the recently published findings from Thienpont, Aronsen, Robinson et al. (JCI 2017) and will contribute to the development of new strategies for enhancing cardiac regeneration and ameliorate disease. The role of the epigenome in determining and maintaining the post-mitotic adult cardiac myocyte phenotype remains to be fully explored and it is important to examine how the epigenome itself can be manipulated to ...
Improving monitoring of cardiac function in critical illness: from advanced echocardiographic technology to metabolic and biochemical biomarkers predicting myocardial dysfunction. KU Leuven
Chapter 1: Validation of a deep neural network which integrates segmentation and as well as deformation imaging analysis in a large image database of echocardiograms. The objective of this chapter is to optimize deep learning techniques through study of a modified neural network, currently in development by the team of Jan D’hooge. This modified neural network will integrate local morphology of the myocardium derived from automated ...
Osteoglycin: A master regulator of cardiac inflammation, fibrosis and function. KU Leuven
Heart failure, the leading cause of mortality in Western society, is the inability of the heart to supply enough blood to meet the body’s needs. Matricellular proteins, nonstructural extracellular proteins, are crucial in regulating the structural and molecular changes needed for survival. Osteoglycin is a recently identified matricellular protein. Our group obtained preliminary data that suggest Osteoglycin may influence cardiac fibrosis, ...
Personalized Cardiac Function Estimation from Volumetric Ultrasound Images KU Leuven
Cardiac arrhythmias are a leading cause of death worldwide. Although different heart rhythm disorders can be recognized using the electrocardiogram, the precise three-dimensional spatiotemporal organization of cardiac activation patterns inside the heart during certain arrhythmia types is not well understood. Commonly, invasive catheter recordings are needed to record electrograms that hint at the location of abnormal sources or re-entrant ...