Projects
Improving current cancer detection and treatment follow up through the development of next generation cancer assays. University of Antwerp
Improving current cancer detection and treatment follow-up through the development of a next generation cancer assay. University of Antwerp
Sexual, psychological and relational functioning in women after surgical treatment for gynaecological cancer and breast cancer KU Leuven
Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs). KU Leuven
The role of the Protein Phosphatase 2A Activator PTPA in KRAS-mutant non-small-cell lung cancer development and treatment resistance KU Leuven
Reversible protein phosphorylation, catalyzed by kinases and phosphatases, is arguably one of the most prominent signaling mechanisms in the human cell. Protein Phosphatase 2A (PP2A) is a major family of Serine/Threonine protein phosphatases of which the members are involved in a broad array of cellular processes, such as mitogenic signaling, growth, cell division, DNA transcription, protein translation, DNA damage signaling and repair, ...
Vitamin D analogs in combination with palbociclib as treatment for triple-negative breast cancer – preclinical evaluation and pathway analysis KU Leuven
1,25(OH)2D3, the biological active form of vitamin D3, is an important regulator of calcium and phosphate homeostasis in the body. By binding to the vitamin D receptor (VDR) and subsequent heterodimerization with the retinoid X receptor (RXR), this complex will migrate to the nucleus and bind to vitamin D responsive elements (VDREs) in regulatory regions of target genes to regulate gene transcription. Next to calcium and phosphate ...
Impact of increased adiposity on breast cancer biology and treatment efficacy KU Leuven
Homologous Recombination Deficiency (HRD) as predictive and prognostic genetic marker in ovarian cancer - Bridging the gap between ‘one-size-fits-all’ and a more personalised treatment approach KU Leuven
Bifidobacterium ameliorates and prevents the imbalance of flora caused by antibiotic treatment of colon cancer Ghent University
This project would investigate the effect of Bifidobacterium supplements on the imbalance of gut microbiota caused by antibiotic treatment relevant to colon cancer. It would also fully investigate the effect and mechanism of Bifidobacterium in the treatment and prevention of colon cancer through cellular and animal models. These results will provide greater understanding and help in the treatment of colon cancer.