Projects
Cell biology of the endo-/lysosomal proteostasis in cancer and neurodegeneration (LYSOCaN). KU Leuven
Pancreatic cancer: study of tumor biology and EMT with testing of corresponding drugs in a relevant pre-clinical model KU Leuven
Exploiting microbial genomics and synthetic biology for discovery and optimisation of novel natural product therapeutics KU Leuven
Microorganisms produce a wealth of structurally diverse natural products with potent biological activities, such as antibiotics, insecticides, fungicides, immunosuppressants and anticancer agents. Microbial natural products and their (semi-) synthetic derivatives therefore have important applications in medicine and agriculture. The continuing rise in resistance to antibiotics and cancer chemotherapeutics remains one of the major concerns for ...
Understanding the role of the WNT signaling pathway in breast cancer dormancy, therapy resistance and cancer relapse. KU Leuven
Breast cancer is the most common and most deadly neoplastic disease among women worldwide. Triple-negative breast cancer is a subtype of breast cancer characterized by the lack of expression of hormone and growth factor receptors, highly aggressive clinical features, poor prognosis, and high relapse rates. The lack of hormone and growth factor receptors renders targeted therapies that are highly efficient in other breast cancer subtypes ...
Improving current cancer detection and treatment follow up through the development of next generation cancer assays. University of Antwerp
Improving current cancer detection and treatment follow-up through the development of a next generation cancer assay. University of Antwerp
Pilot project "population-based study into colorectal cancer". University of Antwerp
To understand and suppress liver cancer cell plasticity and evolution KU Leuven
LncRNAs as modulators of protein synthesis rewiring in cancer KU Leuven
An increasing body of evidence indicates that MYC and RAS-induced oncogenic signalling enhances protein synthesis in both the cytosol and mitochondria and that this increase is essential to cancer cell survival. Targeting translational rewiring may therefore offer novel therapeutic opportunities. However, given its essential role in normal cells, modulating translation in a cancer-cell specific manner remains a major challenge. LncRNA (Long ...