Mechanism of ADAMTS5-impaired brown adipose tissue development and browning of white adipose tissue. KU Leuven
The prevalence of obesity and its associated conditions has reached alarming proportions in modern society. Adipose tissue (AT) mass grows continuously throughout life and is determined by a complex coordination of extracellular matrix remodeling, adipocyte and new blood vessel formation. We have shown that expression of the aggrecanase ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin type 1 motif-5) increases during AT ...