Publications
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Modeling brain dynamics after tumor resection using The Virtual Brain Ghent University University of Antwerp
Brain tumor patients scheduled for tumor resection often face significant uncertainty, as the outcome of neurosurgery is difficult to predict at the individual patient level. Recently, simulation of the activity of neural populations connected according to the white matter fibers, producing personalized brain network models, has been introduced as a promising tool for this purpose. The Virtual Brain provides a robust open source framework to ...
Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood brain barrier permeability Vrije Universiteit Brussel
Aims: The cytoplasmic calcium concentration ([Ca2+]i) is an important factor determining the permeability of endothelial cell layers but little is known on the effect of [Ca2+]i dynamics on endothelial function. Here, we applied several conditions that trigger [Ca2+]i oscillations and cell-to-cell propagating Ca2+ waves, and determined the involvement of connexin channels and consequent effects on endothelial barrier function, in model systems ...
Lost dynamics and the dynamics of loss: Longitudinal compression of brain signal variability is coupled with declines in functional integration and cognitive performance KU Leuven
Reduced moment-to-moment blood oxygen level-dependent (BOLD) signal variability has been consistently linked to advanced age and poorer cognitive performance, showing potential as a functional marker of brain aging. To date, however, this promise has rested exclusively on cross-sectional comparisons. In a sample of 74 healthy adults, we provide the first longitudinal evidence linking individual differences in BOLD variability, age, and ...
Altered transient brain dynamics in multiple sclerosis Vrije Universiteit Brussel
Multiple sclerosis (MS) is a demyelinating, neuroinflammatory, and -degenerative disease that affects the brain's neurophysiological functioning through brain atrophy, a reduced conduction velocity and decreased connectivity. Currently, little is known on how MS affects the fast temporal dynamics of activation and deactivation of the different large-scale, ongoing brain networks. In this study, we investigated whether these temporal dynamics ...
Connexin channels provide a target to manipulate calcium dynamics and blood brain barrier permeability Ghent University
Resting brain fluctuations are intrinsically coupled to visual response dynamics University of Antwerp
How do intrinsic brain dynamics interact with processing of external sensory stimuli? We sought new insights using functional magnetic resonance imaging to track spatiotemporal activity patterns at the whole brain level in lightly anesthetized mice, during both resting conditions and visual stimulation trials. Our results provide evidence that quasiperiodic patterns (QPPs) are the most prominent component of mouse resting brain dynamics. These ...
Developmental brain dynamics of numerical and arithmetic abilities KU Leuven
The development of numerical and arithmetic abilities constitutes a crucial cornerstone in our modern and educated societies. Difficulties to acquire these central skills can lead to severe consequences for an individual's well-being and nation's economy. In the present review, we describe our current broad understanding of the functional and structural brain organization that supports the development of numbers and arithmetic. The existing ...
Resting brain fluctuations are intrinsically coupled to visual response dynamics University of Antwerp
How do intrinsic brain dynamics interact with processing of external sensory stimuli? We sought new insights using functional (f)MRI to track spatiotemporal activity patterns at the whole brain level in lightly anesthetized mice, during both resting conditions and visual stimulation trials. Our results provide evidence that quasiperiodic patterns (QPPs) govern mouse resting brain dynamics. QPPs captured the temporal alignment of global brain ...
Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability KU Leuven Ghent University
The cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) is an important factor determining the functional state of blood-brain barrier (BBB) endothelial cells but little is known on the effect of dynamic [Ca(2+)](i) changes on BBB function. We applied different agonists that trigger [Ca(2+)](i) oscillations and determined the involvement of connexin channels and subsequent effects on endothelial permeability in immortalized and primary brain ...