Retinoic acid and palatogenesis KU Leuven
Orofacial clefts (OFC) are among the most common birth defects in humans. OFC can be syndromic and non-syndromic. One of the main syndromic forms occurs in the transcription factor TP63-related syndromes, in which OFC appears as the cardinal feature together with ectodermal dysplasia and limb malformations. Vitamin A is an important regulator of embryonic proliferation, differentiation and apoptosis. Its active metabolite retinoic acid (RA) ...