Analysis of plasma, platelets and urine nucleic acids: the value of liquid biopsy to improve diagnosis, follow-up and monitoring of treatment response of lung cancer and pancreatic cancer patients. University of Antwerp
Importance of a reliable diagnosis of myometrial lesions using ultrasonography and liquid biopsy biomarkers in clinical gynecological practice. KU Leuven
Malignant myometrial lesions (sarcomas) are highly aggressive and require radical surgery in an oncological centre. Benign myometrial lesions (myomas) may either be managed expectantly, treated medically or by selective uterine artery embolisation or surgically by laparoscopic myomectomy with morcellation. It is of utmost importance to accurately identify sarcomas, not only because any delay in diagnosis is associated with lower survival ...
Early prediction/detection of clinical response in metastatic NSCLC by improving liquid biopsy analysis KU Leuven
Non Small Cell Lung Cancer (NSCLC) patients are often treated with chemotherapy, which are toxic and can potentially lead to serious, even life-threatening side effects. Also, the quality of life can deteriorate. Unfortunately, not all patients respond to this treatment resulting in unnecessary treatment of these patients. Detecting the response at an early stage, preferably by a minimally or non-invasive alternative to tissue biopsies is ...
Cobioto, Corneale Biopsy Tool. University of Antwerp
Pan-cancer liquid biopsy screening for the identification of actionable RNA biomarkers Ghent University
The biggest challenges in cancer patient management are the use of more effective and less toxic treatmant modalities, better and less invasive methods to diagnose disease, to select the right drug, to monitor treatment response and to identify relapse disease early-on. Our project proposal aims to address several of these issures by the introduction of RNA based liquid biopsy guided precision oncology. We will screen easy-to-obtain plasma ...
Molecular analysis of cell free circulating DNA (cfDNA) and/or circulating tumour cells (CTC) as 'liquid biopsy' for predictive biomarker assessment in patients with metastatic colorectal cancer (mCRC). University of Antwerp
A metabolomics signature on liquid biopsy as a prognostic and predictive biomarker in early breast cancer KU Leuven
We will compare the metabolomics profile of large cohorts of breast cancer patients with documented treatment outcome in order to identify candidate biomarkers of treatment response or recurrence risk. Such identification fo non-responder patients and of patients at risk of relapse could help define those patients likely to benefit from neoadjuvant escalation treatment and those who might benefit from de-escalation strategies.
Biopsychosocial mechanisms of chronic fatigue syndrome and their relevance for rehabilitation KU Leuven
About 20 000 people in Belgium suffer from chronic fatigue syndrome (CFS), a disorder characterized by persisting fatigue insufficiently explained by known medical or psychiatric conditions. Individuals suffering from CFS experience severe limitations in daily functioning due to their fatigue. Despite intensive research over the past decades, the (psycho)physiological dysfunctions generating CFS symptoms remain poorly understood, and no ...