Projects
New AlF chelators for fluorine-18 radiolabeling of biomolecules KU Leuven
Positron emission tomography (PET) uses a PET scanner to track radioactive molecules in the body. Fluorine-18 (18F, a radioactive form of fluorine) is a frequently used radionuclide used in PET. The chemical incorporation of 18F into biological molecules (biomolecules) allows visualization of the binding of the biomolecule to its target in the body using a PET scanner. The Al18F method allows to incorporate 18F in various biomolecules in a ...
Electrical separation of biomolecules using nanostructures KU Leuven
This PhD focuses on the development of an electro-capturing method and device for the separation and enrichment of biomolecules in a microfluidic context. Nucleic acids can be manipulated efficiently using electric fields due to an abundance of negative charges. These charges allow fast electrophoretic migration in an electric field, this property is widely exploited in DNA gel electrophoresis. It is however, not straightforward to scale this ...
Molecular insight into interactions between MOF-based nanozymes and biomolecules using x-ray absorption fine structure (XAFS) spectroscopy KU Leuven
The hydrolysis of proteins is a challenging task due to the inertness of the peptide bond, yet it is crucial for many applications in biotechnology and proteomics. Nanozymes, i.e., nano-engineered materials that function as artificial enzymes, can promote protein fragmentation and overcome some of the key issues associated with proteolytic enzymes, such as high cost and low stability. Metal-organic frameworks (MOFs) based on Zr and Ce metals ...
Machine-learning-enhanced identification of electron transporting biomolecules in electroactive microorganisms using combined Timeof- Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Scanning Probe Microscopy (SPM) data. Hasselt University
Machine-learning-enhanced identification of electron transporting biomolecules in electroactive microorganisms using combined Timeof- Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Scanning Probe Microscopy (SPM) data. Hasselt University
Lipid-coated zero-mode wave-guide (ZMW) nanopores for single-molecule investigations of biomolecules. KU Leuven
Single-molecule (SM) methods provide a powerful way to investigate e.g. transient subpopulations and the dynamics of enzymes, features that are usually obscured by ensemble averaging. The rapid expansion of these technologies is revolutionizing our ability to probe the mechanisms of biological reactions in biological systems of ever-increasing complexity. Technological improvements have made it possible to combine several different ...
Electrophoretic deposition of biomolecules via unbalanced alternating fields. KU Leuven
The project concerns the modification of the surface chemistry of biomaterials by depositing bioactive molecules.