Projects
Identification of pan-cancer and tumor-specific methylation based biomarkers and development of bioinformatics infrastructure for a novel multiplex methylation assay. University of Antwerp
PhD position in Bioinformatics and Genomics KU Leuven
De nieuwe generatie sequencing technoligieën zijn deel geworden van het klinisch diagnostisch process. Recentelijk werd ook volledige genoom analyse (WGS) toegankelijk voor de routine diagnostiek en zijn we deze methodiek aan het implementeren. Een eerste doelstelling van deze Ph.D thesis is om WGS analyse te implementeren, te standardiseren en de beschikbare algorithmen verder te optimaliseren voor variatie analyse en de kwaliteitsparameters ...
Bioinformatics for a high-throughput deep mutational scanning protein-protein interaction assay: turning a prototype into a precision medicine toolbox Ghent University
This proposal contributes to the development of a high-throughput method to characterize the impact of nearly every mutation on specific protein-protein interactions. After bioinformatics-driven experimental optimization, this method will be applied to tumor-driver protein interactions (TP53, PTEN, PIK3R1) and results compared to large-scale tumor mutation and gene expression data. This will allow to demonstrate the major relevance for ...
Special Research Fund Professorship in Translational genomics and bioinformatics Ghent University
A professorship granted by the Special Research Fund is a primarily research-oriented position and is made available for excellent researchers with a high-quality research programme.
Educating Experts of the Future: Developing Bioinformatics and Biostatistics competencies of European Biomedical Students - Becoming Hasselt University
Plant Health Bioinformatics Network Research Institute for Agriculture, Fisheries and Food
Plant disease detection by high throughput sequencing (HTS) is a relatively new and fast developing discipline, with very variable levels of expertise in (diagnostic) phytopathology laboratories across Europe. Especially the accompanying bioinformatics analyses are a large hurdle to take for many plant pathology labs, and a lack of standards / best practices complicates this even more. In this project, we ...
Improved infectious diseases control in Peru through sustainable capacity building for bioinformatics and genome sequencing. University of Antwerp
Optimization of a Bioinformatics Pipeline to Investigate the Role of the Human Gut Virome in Human Diseases KU Leuven
During my PhD thesis, I will work on an optimized pipeline to identify bacteriophages from viral metagenomics data. Furthermore, I will apply this tool together with other tools optimized in the lab to study the role of the gut virome (viral part of the gut microbiota) in relationship to human diseases such as inflammatory Bowel Disease (IBD). More in particular, I will analyze the gut virome in longitudinal samples from Ulcerative Colitis ...
Unravelling cellular heterogeneity and dynamics in normal and malignant hematopoiesis using singlecell bioinformatics Ghent University
In this multi-disciplinary project, we will pioneer the development and application of single-cell genomics to study the heterogeneity and dynamics of the immune system.
Our consortium will pioneer the role of single-cell genomics at Ghent University, developing novel bioinformatics approaches to study cell differentiation and dynamics, and combining them with both fundamental research in immunology as well as clinical applications.