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Validation report AnticFast® Beta-Lactams & Tetracyclines & Cefalexin Rapid Test Kit (Order n°: JC0641) (Meizheng Group, Beijing, China) Research Institute for Agriculture, Fisheries and Food
Validation report AnticFast® Beta-Lactams & Tetracyclines Combo Test Kit (Meizheng Group, Beijing, China) Research Institute for Agriculture, Fisheries and Food
Validation report AnticFast® Beta-lactams Rapid Test Kit (Meizheng Group, Beijing, China) Research Institute for Agriculture, Fisheries and Food
Validation report AnticFast® Beta-Lactams & Tetracyclines & Sulfonamides Rapid Test Kit (Order n°: JC0458) (Meizheng Group, Beijing, China) Research Institute for Agriculture, Fisheries and Food
Diastereoselective Synthesis of Bicyclic gamma-Lactams via Ring Expansion of Monocydic beta-Lactams Ghent University
cis-4-(1-Chloro-1-methylethyl)-1-(omega-hydroxyalkyl)azetidin-2-ones were diastereoselectively transformed into novel trans-1-aza-4-oxabicyclo[3.3.0]octan-8-ones and trans-1-aza-5-oxabicyclo[4.3.0]nonan-9-ones upon treatment with 1 equiv of AgBF4 and pyridine in toluene via intramolecular nucleophilic trapping of N-acyliminium intermediates by the hydroxyl moiety. Additionally.. the corresponding aza-analogues of the aforementioned bicyclic ...
Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody Vrije Universiteit Brussel
MβL (metallo-β-lactamase) enzymes are usually produced by multi-resistant Gram-negative bacterial strains and have spread worldwide. An approach on the basis of phage display was used to select single-domain antibody fragments (VHHs, also called nanobodies) that would inhibit the clinically relevant VIM (Verona integron-encoded MβL)-4 MβL. Out of more than 50 selected nanobodies, only the NbVIM_38 nanobody inhibited VIM-4. The paratope, ...
Diversity of extended-spectrum β-lactamases and class C β-lactamases among cloacal Escherichia coli isolates in Belgian broiler farms Research Institute for Agriculture, Fisheries and Food Ghent University University of Antwerp
A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity of this resistance at the farm level. Strains were examined for resistance against beta-lactam antibiotics and other antimicrobial agents by using disk diffusion tests. Three different beta-lactam resistance phenotypes suggested the presence of an ...
Crystallization and preliminary X-ray diffraction analysis of kanamycin-binding β-lactamase in complex with its ligand Vrije Universiteit Brussel
TEM-1 beta-lactamase is a highly efficient enzyme that is involved in bacterial resistance against beta-lactam antibiotics such as penicillin. It is also a robust scaffold protein which can be engineered by molecular-evolution techniques to bind a variety of targets. One such beta-lactamase variant (BlaKr) has been constructed to bind kanamycin (kan) and other aminoglycoside antibiotics, which are neither substrates nor ligands of native ...