Immunohistochemical evidence for Zic1 coexpression with beta-catenin in the myofibroblast of Dupuytren disease KU Leuven
The active cellular component in Dupuytren disease (DD) is alpha-smooth muscle actin (alpha-SMA)containing myofibroblasts. The underlying regulatory processes in activation of myofibroblasts resemble the pathophysiology of certain types of cancer. Accumulation of beta-catenin has been shown in many fibroproliferative processes, including DD and recent findings attributed a possible role to the Zicl transcription factor. To assess Zicl expression ...