Multi Omics Data Integration to predict the M. tuberculosis Bedaquiline Resistance Phenotype from the Genotype Institute of Tropical Medicine
Department of Biomedical Sciences, Management, University of Colorado Colorado Springs, Nottingham Trent University, Maastricht University, Harvard University, University of Antwerp, Mycobacteriology
Drug resistance is caused by DNA mutations in certain Mycobacterium tuberculosis genes, which in turn modify or effect drug targeted proteins (enzymes) directly or indirectly.
Currently, clinical research on the best combinations in which to use new drugs suffers from a genotype-phenotype gap: we can test for resistance in the lab (phenotype) but we can’t predict the phenotype from
mutations. Resistance testing for Bedaquiline is ...
Currently, clinical research on the best combinations in which to use new drugs suffers from a genotype-phenotype gap: we can test for resistance in the lab (phenotype) but we can’t predict the phenotype from
mutations. Resistance testing for Bedaquiline is ...