Projects
From hit to lead: inducing basal autophagy for treating cardiovascular diseases. University of Antwerp
Specific blocking of autophagy processess via inhibition of Atg4B? An approach based on drug-like inhibitors and activity-based probes. University of Antwerp
Development of an in vivo autophagy modulation model of the rat liver using adeno-associated virus-mediated delivery of shRNA KU Leuven
Recovery from critical illness: role of autophagy and epigenetics. KU Leuven
The development of critical care medicine over the last 50 years allowed patients to survive acute life-threatening conditions. Whereas most of these patients recover within a few days, a substantial number of critically ill patients develop multiple organ failure (MOF), which prolongs the dependency on intensive care and increases health care costs. Despite major advances in intensive medical care, MOF is still a leading cause of morbidity ...
The role of lysosomal Ca2+ in the regulation of autophagy KU Leuven
The ER is the largest organelle found in the cell and acts as the largest Ca2+ store, with a [Ca2+]ER around 500 µM while the [Ca2+]cyt is around 100 nM. Various proteins, including the SERCA pump and the IP3 receptor, regulate the Ca2+ content of the ER. The high [Ca2+]ER is important for the role of Ca2+ as second messenger, but also for the proper functioning of the ER chaperones involved in the folding of newly synthesised proteins and in ...