Modulation of astrocyte activation in murine iPSC-derived neurospheroids. University of Antwerp
Functional and molecular profiling of immune-competent neurospheroids under stroke-like conditions. University of Antwerp
Investigation of functional immune cell-astrocyte interaction and its contribution to Neuroinflammation KU Leuven
Neurological function and dysfunction are controlled by complex biological responses involving the coordinated activities of multiple cell types in the central nervous system (CNS). A growing body of evidence points to the importance of the reciprocal communication between CNS-resident cells and the immune system for CNS physiology. Integration of the glial compartment as an active participant in neuroimmune processes is paramount. My key ...
Danio rerio: a “humanized” in vivo model for the study of non-cell autonomous mechanisms in ALS KU Leuven
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the loss of both upper and lower motor neurons (MNs). In this regard, in the last years the non-cell autonomous contribution of reactive astrocytes has been considered as extremely influential to the course of the pathology. Unfortunately, in-vitro 2D cultures and mouse models are not capable to fully recapitulate molecular pathological features and motor ...