Molecular determinants of Bcl–2 and Bcl–Xl binding to the IP3R channel and regulation of its activity at the molecular and functional level in normal and apoptotic cells KU Leuven
B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-Xl) are major anti-apoptotic proteins, members of the Bcl-2 family, which have a key role in the regulation of cell-fate decisions. Bcl-2 and Bcl-Xl share all four B-cell homology (BH1-4) domains, with an N-terminal BH4 domain and a hydrophobic cleft formed by the BH3-BH2-BH1 domains. Bcl-2 and Bcl-Xl also possess a C-terminal trans-membrane domain (TMD), which is responsible for ...