Publications
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Mining phages as a source for novel anti-virulence approaches against Pseudomonas aeruginosa KU Leuven
The opportunistic pathogen Pseudomonas aeruginosa is endowed with a broad arsenal of virulence factors which enables it to cause both acute and chronic infections. In addition, due to its resistance against almost all conventional antibiotics, it is considered as one of the life-threatening 'superbugs' for which the development of novel antibiotics is of critical importance. Consequently, innovative strategies are needed to tackle the increasing ...
Origanum vulgare ethanolic extracts as a promising source of compounds with antimicrobial, anti-biofilm, and anti-virulence activity against dental plaque bacteria KU Leuven
Dental caries and periodontal diseases remain a challenge for oral health, especially given the lack of effective and safe treatment options that are currently available. Against the backdrop of an ongoing antimicrobial resistance crisis, a renewed interest in traditional medicinal plants as a potential source of new bioactive compounds has surfaced. In this context, we systematically screened the antimicrobial and anti-biofilm activities of ...
The Anti-Virulence Effect of Sub-Minimal Inhibitory Concentrations of Levofloxacin on Hypervirulent Klebsiela pneumoniae KU Leuven
BACKGROUND: Hypervirulent Klebsiella pneumoniae (hvKp) is best described as a virulent pathogen and generally associated with the hypermucoviscosity phenotype. Increased capsule and aerobactin production are established important hvKp-specific virulence factors. Although hvKp strains have been relatively susceptible to antimicrobials, given the high morbidity and mortality, there is a critical need for alternative strategies for the treatment of ...
Validation of UDPG:PP as an anti‐virulence drug target against Streptococcus pneumoniae infections using Galleria mellonella as an alternative in vivo model University of Antwerp
The pneumococcus Streptococcus pneumoniae is considered one of the most important human pathogens. Infection can lead to diseases such as meningitis, pneumonia and otitis media. Especially children, the elderly and immunocompromised patients are at risk for developing severe infections. While several vaccines exist, they do not cover the entire pneumococcal spectrum. Moreover, a switch towards non-vaccine serotypes has been observed. Also, ...
The type II secretion system and membrane vesiculation : bacterial secretion systems as a target for anti-virulence drug development Ghent University
Indole signaling, a promising target to control vibriosis in aquaculture Ghent University
Diseases caused by pathogenic vibrios result in major losses in aquaculture. The use of antibiotics in order to control these infections has led to the development and spread of antibiotic-resistant pathogens, rendering antibiotic treatments ineffective and causing problems for food safety. Therefore, novel methods to control vibriosis are needed. A promising alternative is the interference with quorum sensing, bacterial cell-to-cell ...
Quorum-sensing interference in vibrios Ghent University
Vibrios belonging to the Harveyi clade and the Splendidus clade are important pathogens that cause high economic losses in aquaculture. To control bacterial diseases, antibiotics have been widely applied in aquaculture worldwide for many years, contributing to the development and spread of antibiotic resistance. To further limit the use of antibiotics without affecting the envisaged sustainable growth of the sector, novel therapies to control ...
The specific capsule depolymerase of phage PMK34 sensitizes Acinetobacter baumannii to serum killing Ghent University KU Leuven
The rising antimicrobial resistance is particularly alarming for Acinetobacter baumannii, calling for the discovery and evaluation of alternatives to treat A. baumannii infections. Some bacteriophages produce a structural protein that depolymerizes capsular exopolysaccharide. Such purified depolymerases are considered as novel antivirulence compounds. We identified and characterized a depolymerase (DpoMK34) from Acinetobacter phage vB_AbaP_PMK34 ...