Publications
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Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. Vrije Universiteit Brussel
Pilicides block pili formation by binding to pilus chaperones and blocking their function in the chaperone/usher pathway in E. coli. Various C-2 substituents were introduced on the pilicide scaffold by design and synthetic method developments. Experimental evaluation showed that proper substitution of this position affected the biological activity of the compound. Aryl substituents resulted in pilicides with significantly increased potencies as ...
QseC inhibition as a novel antivirulence strategy for the prevention of Acute Hepatopancreatic Necrosis Disease (AHPND)-causing Vibrio parahaemolyticus Ghent University
Erratum for Oliveira et al., “Functional Analysis and Antivirulence Properties of a New Depolymerase from a Myovirus That Infects Acinetobacter baumannii Capsule K45” Hasselt University KU Leuven
Quorum-sensing systems as targets for antivirulence therapy Ghent University
Specific antivirulence activity, a new concept for reliable screening of virulence inhibitors Ghent University
Antivirulence therapy, disarming pathogens rather than killing them, is emerging as a novel strategy for disease control. Reporter strains expressing an easily measurable and quantifiable phenotype enable easy screening of virulence inhibitors. In this paper I propose a novel concept to exclude false positives in this type of screening.
Virulence mechanisms of bacterial aquaculture pathogens and antivirulence therapy for aquaculture Ghent University
Antivirulence therapy for animal production : filling an arsenal with novel weapons for sustainable disease control Ghent University
Identification of potential antivirulence agents by substitution- oriented screening for inhibitors of Streptococcus pyogenes sortase A KU Leuven
Antimicrobial resistance resulting in ineffective treatment of infectious diseases is an increasing global problem, particularly in infections with pathogenic bacteria. In some bacteria, such as Streptococcus pyogenes, the pathogenicity is strongly linked to the attachment of virulence factors. Their attachment to the cellular membrane is a transpeptidation reaction, catalyzed by sortase enzymes. As such, sortases pose an interesting target for ...
Targeting Pseudomonas aeruginosa in the sputum of primary ciliary dyskinesia patients with a combinatorial strategy having antibacterial and anti-virulence potential Ghent University
In primary ciliary dyskinesia (PCD) patients, Pseudomonas aeruginosa is a major opportunistic pathogen, frequently involved in chronic infections of the lower airways. Infections by this bacterial species correlates with a worsening clinical prognosis and recalcitrance to currently available therapeutics. The antimicrobial peptide, lin-SB056-1, in combination with the cation chelator ethylenediaminetetraacetic acid (EDTA), was previously ...