Projects
Antimicrobial resistance - impact of cross-contamination of animal feeders with antimicrobials in resistance development. Ghent University
Cross-contamination of feed with antibiotics are possibly not desirable slectiedruk for antibiotic resistance. However, there is little to no literature is available regarding the effect of low doses of antibiotic resistance selection. The main question is whether these low doses have an effect on increasing the selection of resistant bacteria in the gut and the transfer of resistance among bacteria. The answers will contribute to this on the ...
Effect of altered antimicrobial use in food-producing animals on antimicrobial resistance in selected animal and human pathogens: looking back to go further (lessons learned, challenges remaining) Ghent University
To assess the effect of the achieved reduction in AMU and to link it with the AMR trends in animal and human pathogens in Belgium we aim to use as much available data as possible. In that respect, the study will identify and try to include all the relevant data on AMU and AMR as far back as possible both from public and private databases. Whenever databases remain non-accessible for the consortium we will include publicly available reports ...
Next generation pharmacokinetic-pharmacodynamic modeling: dosage regimen for both curative and metaphylactic antimicrobial treatment taking antimicrobial resistance development into account Ghent University
Current dosage regimens of antimicrobials have been determined for curative treatment without taking antimicrobial resistance into account. In this research proposal, optimal dosage regimen will be established for both curative and metaphylactic enrofloxacin treatment against avian pathogenic Escherichia coli in broilers. The effect of these dosage regimen on resistance development in both the target pathogen and the commensal gut microbiota ...
Antimicrobial resistance - Impact of cross contamination of animal feed with antimicrobial agents on resistance development Research Institute for Agriculture, Fisheries and Food
What is the effect of low doses of antibiotics in feed as a consequence of carry-over, on selection of resistant bacteria and transfer of resisance genes in the animal gut? This is the central research question of the Crosscontam project. By carry-over from medicated to non-medicated feed cross contamination of feed with antibiotics may occur. Since 2014, carry-over is mainly located in Belgium ...
Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors KU Leuven
Persistent, untreatable infections pose a substantial financial and medical burden on society. Mycobacterium tuberculosis (Mtb) and BK polyomavirus (BKV) are two endemic species that have persisted for more then a century and over 60 years, respectively. Both infections present ongoing challenges to the public health. Within this thesis, novel lead compounds targeting both infections were discovered. In the first part, the thesis focussed on ...
Development and streamlining a validation and implementation workflow for model-informed precision dosing for biologicals and antimicrobials KU Leuven
Understanding antimicrobials use: An ethnographic study of rural communities in Burkina Faso Institute of Tropical Medicine
Screening and mode of action of natural antimicrobials to control Listeria monocytogenes in foods KU Leuven
Listeria monocytogenes is an important foodborne pathogen for which adequate control measures need to be implemented along the food production chain. The organism is widespread in the natural environment and can thus contaminate raw materials of both plant and animal origin. It can also be found and persist in food production facilities and from there contaminate food products during manufacturing. Despite its wide distribution and frequent ...