Structural analysis of antibody-based profibrinolytics KU Leuven
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor superfamily, is the main physiologic inhibitor of plasminogen activators (PAs). Therefore, PAI-1 carries a flexible reactive center loop (RCL) that presents a substrate-mimicking peptide sequence that inserts into the active site of the PA. After initial complex formation, the reactive center in the RCL is cleaved by the PA which induces a conformational ...