Projects
Evaluating the therapeutic potential of anti-CD6 monoclonal antibody therapy in inflammatory barrier diseases. Hasselt University
The development of a specific monoclonal antibody against deoxynvalenol Ghent University
- the development of monoclonal antibody against deoxynivalenol using the classic hybridoma technique and the recombinant phage display technique. During recombinant antibody technologu the following steps will be used:
-> Construction of antobody library
-> Biopanning of the phage display library
-> Genetic engineering: point mutations
- The determination of deocynivalenol using an ...
Enabling antibody prophylaxis of the elderly and vulnerable using yeast-based biotechnology. Ghent University
Vaccines against respiratory viral infections are likely to lack full efficacy in the most vulnerable aged population group. In this project we develop a yeast-based, cost-effective and highly scalable prototyping-and manufacturing technology for highly potent virus-neutralizing VHH-Fc anitbodies with
engineered prolonged halflife. Such passive immunization strategy complements vaccination-based approaches during peak periods of ...
Intratumoral DNA-based immunomodulatory antibody therapy as a single or combined treatment with irradiation: A pre-clinical proof-of-concept study KU Leuven
An on-chip single B cell mining platform for rapid development of fully human therapeutic antibodies and for immunoprofiling human antibody responses KU Leuven
Next-generation DNA vectors to improve efficacy, precision and accessibility of antibody gene transfer KU Leuven
PharmAbs: K.U.Leuven Antibody Center. KU Leuven
PharmAbs is an innovation, valorization and incubation platform at KU Leuven clustering the expertise of 5 academic groups. PharmAbs initiates and supports translational R&D projects aimed at the development of innovative antibody-based therapeutics or diagnostics or breakthrough antibody technologies. PharmAbs offers its expertise to academic groups and companies through joint R&D partnerships or fee-for-service projects.
...Universal antibody scaffolds with drug-like features for straightforward mini-domain grafting Ghent University
In this project, I will investigate whether mini-domain grafting affects favourable physicochemical properties of antibodies (also known as drug-like properties). I will achieve this by designing a set of model proteins, assessing their expression in production cell lines, and applying a wide range of techniques to analyze the structure, stability and antigen-binding properties of the purified chimeric proteins in comparison to the wild-type ...