Advancing DNA-based antibody therapeutics through evaluation and characterization of in vivo expression, complex antibody formats, and delivery formulations KU Leuven
DNA-based antibody therapy seeks to administer the encoding nucleotide sequence, rather than the antibody protein. This innovative approach can allow the patient’s body to produce its own medicine, and presents an alternative to the complex production and frequent administration of conventional antibody protein therapy. Our research group previously obtained therapeutic proof of concept in mice for several plasmid-encoded antibody formats ...