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No Effect of Continued Antiarrhythmic Drug Treatment on Top of Optimized Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation: Results From the POWDER-AF2 Trial Hasselt University

Anthony Demolder, Louisa O'Neill, Milad El Haddad, Daniel Scherr, Johan VIJGEN, Michael Wolf, Benjamin Berte, Felipe Bisbal, Arne Johannessen, Maximo Rivero-Ayerza, et al.
BACKGROUND: In patients with persistent atrial fibrillation (PersAF), catheter ablation aiming for pulmonary vein isolation (PVI) is associated with moderate clinical effectiveness. We investigated the benefit of continuing previously ineffective class 1C or 3 antiarrhythmic drug therapy (ADT) in the setting of a standardized PVI-only ablation strategy.METHODS: In this multicenter, randomized controlled study, patients with PersAF (>= 7 days ...

Synergistic antiarrhythmic effect of inward rectifier current inhibition and pulmonary vein isolation in a 3D computer model for atrial fibrillation Vrije Universiteit Brussel

Ali Gharaviri, Simone Pezzuto, Mark Potse, Giulio Conte, Stef Zeemering, Vladimír Sobota, Sander Verheule, Rolf Krause, Angelo Auricchio, Ulrich Schotten, et al.

AIMS: Recent clinical studies showed that antiarrhythmic drug (AAD) treatment and pulmonary vein isolation (PVI) synergistically reduce atrial fibrillation (AF) recurrences after initially successful ablation. Among newly developed atrial-selective AADs, inhibitors of the G-protein-gated acetylcholine-activated inward rectifier current (IKACh) were shown to effectively suppress AF in an experimental model but have not yet been evaluated ...

Prophylactic antiarrhythmic drug therapy in atrial fibrillation Vrije Universiteit Brussel

Moises Rodríguez-Mañero, Andrea Sarkozy, Gian Battista Chierchia, Rubén Casado Arroyo, Danilo Ricciardi, Carlo de Asmundis, Andrea Carlo de, Pedro Sarkozy

In patients with recurrent atrial fibrillation (AF), the hallmark of treatment has been the use of antiarrhythmic drugs (AADs). Goals of therapy include reduction in the frequency and duration of episodes of arrhythmia as well an emerging goal of reducing mortality and hospitalizations associated with AF. Safety and efficacy are important factors when choosing an antiarrhythmic drug for the treatment of AF, hence, if AAD are required for ...

Contemporary clinical management of monomorphic idiopathic premature ventricular contractions: results of the European Heart Rhythm Association survey Vrije Universiteit Brussel

Antonio Sorgente, José M Guerra, Kristine Jubele, Julian K R Chun, Carlo de Asmundis, Serge Boveda
On behalf of the European Heart Rhythm Association, we designed a survey, whose aim was to understand the trend(s) in the clinical management of idiopathic monomorphic premature ventricular contractions (PVCs) among European cardiologists and cardiac electrophysiologists. A total of 202 participants in the survey answered 27 multiple-choice questions on the clinical presentation, diagnosis and treatment of idiopathic monomorphic PVCs. The most ...

Contemporary clinical management of monomorphic idiopathic premature ventricular contractions: results of the European Heart Rhythm Association survey Vrije Universiteit Brussel

Antonio Sorgente, José M Guerra, Kristine Jubele, Julian K R Chun, Carlo de Asmundis, Serge Boveda
On behalf of the European Heart Rhythm Association, we designed a survey, whose aim was to understand the trend(s) in the clinical management of idiopathic monomorphic premature ventricular contractions (PVCs) among European cardiologists and cardiac electrophysiologists. A total of 202 participants in the survey answered 27 multiple-choice questions on the clinical presentation, diagnosis and treatment of idiopathic monomorphic PVCs. The most ...

Added value of patient- and drug-related factors to stratify drug-drug interaction alerts for risk of QT prolongation: Development and validation of a risk prediction model Vrije Universiteit Brussel University of Antwerp

Katoo Muylle, Sven Van Laere, Luigi Pannone, Samuel Coenen, Carlo de Asmundis, Alain Dupont, Pieter Cornu
Aims: Many clinical decision support systems trigger warning alerts for drug-drug interactions potentially leading to QT prolongation and torsades de pointes (QT-DDIs). Unfortunately, there is overalerting and underalerting because stratification is only based on a fixed QT-DDI severity level. We aimed to improve QT-DDI alerting by developing and validating a risk prediction model considering patient- and drug-related factors. Methods: We fitted ...

Added value of patient- and drug-related factors to stratify drug-drug interaction alerts for risk of QT prolongation: Development and validation of a risk prediction model Vrije Universiteit Brussel University of Antwerp

Katoo Muylle, Sven Van Laere, Luigi Pannone, Samuel Coenen, Carlo de Asmundis, Alain Dupont, Pieter Cornu
Aims: Many clinical decision support systems trigger warning alerts for drug-drug interactions potentially leading to QT prolongation and torsades de pointes (QT-DDIs). Unfortunately, there is overalerting and underalerting because stratification is only based on a fixed QT-DDI severity level. We aimed to improve QT-DDI alerting by developing and validating a risk prediction model considering patient- and drug-related factors. Methods: We fitted ...

Catheter ablation in patients with paroxysmal atrial fibrillation and absence of structural heart disease: A meta-analysis of randomized trials Vrije Universiteit Brussel

Antonio Parlavecchio, Giampolo Vetta, Giovanni Coluccia, Lorenzo Pistelli, Rodolfo Caminiti, Manuela Ajello, Michele Magnocavallo, Giuseppe Dattilo, Rosario Foti, Scipione Carerj, et al.
Introduction: Rhythm control strategy in paroxysmal atrial fibrillation (AF) can be performed with antiarrhythmic drugs (AAD) or catheter ablation (CA). Nevertheless, a clear overview of the percentage of freedom from AF over time and complications is lacking. Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) comparing CA versus AAD. Methods: We searched databases up to 5 May 2023 for RCTs focusing on CA versus AAD. ...

Catheter Ablation versus Medical Therapy of Atrial Fibrillation in Patients with Heart Failure: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials Vrije Universiteit Brussel

Michele Magnocavallo, Antonio Parlavecchio, Giampolo Vetta, Carola Gianni, Marco Polselli, Francesco De Vuono, Luigi Pannone, Sanghamitra Mohanty, Filippo Maria Cauti, Rodolfo Caminiti, et al.
Background: Atrial fibrillation (AF) and heart failure (HF) often coexist and synergistically contribute to an increased risk of hospitalization, stroke, and mortality. Objective: To compare the efficacy of catheter ablation (CA) versus medical therapy (MT) in HF patients with AF. Methods: Electronic databases were queried for randomized controlled trials (RCTs) of CA versus MT of AF in patients with HF. Risk ratios (RRs), mean differences ...

Catheter Ablation versus Medical Therapy of Atrial Fibrillation in Patients with Heart Failure: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials Vrije Universiteit Brussel

Michele Magnocavallo, Antonio Parlavecchio, Giampolo Vetta, Carola Gianni, Marco Polselli, Francesco De Vuono, Luigi Pannone, Sanghamitra Mohanty, Filippo Maria Cauti, Rodolfo Caminiti, et al.
Background: Atrial fibrillation (AF) and heart failure (HF) often coexist and synergistically contribute to an increased risk of hospitalization, stroke, and mortality. Objective: To compare the efficacy of catheter ablation (CA) versus medical therapy (MT) in HF patients with AF. Methods: Electronic databases were queried for randomized controlled trials (RCTs) of CA versus MT of AF in patients with HF. Risk ratios (RRs), mean differences ...