Hypoxia-mediated DNA demethylation events underlying adaptive resistance to anti-angiogenic therapies. KU Leuven
Blood vessels crucially deliver oxygen and nutrients to cells throughout the body. Tumors similarly develop a vascular network for nutrient and oxygen supply, but tumor vessels are distinct from normal blood vessels as they are hyperactive and leaky, rendering them dysfunctional. This difference makes the tumor vasculature an excellent therapeutic target to slow tumor growth. Indeed, anti-angiogenic therapies have been successfully developed ...