Projects
Real-time monitoring of complex surgical lab animal models KU Leuven
Reproductive System on a Chip (ReproSyC):next-generation multi-organ modeling of the human reproductive system to replace animal models KU Leuven
From exposome to effect assessment of contaminants in human and animal models (EXPOSOME). University of Antwerp
Precision medicine in inherited blindness using integrated omics in human and animal models Ghent University
This multidisciplinary project aims (1) to decipher cis-Âregulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-Âbased treatments of novel targets, ultimately resulting in precision medicine ...
A platform to functionally assess clinically relevant respiratory parameters in small animal models for infectious and non-infectious pulmonary research. University of Antwerp
Role of angiogenesis and angiogenic growth factors (VEGF, PLGF) in portal hypertension and fibrosis formation in animal models of cirrhosis, steatosis and portal hypertension Ghent University
Models of portal hypertension and cirrhosis are used to study prevention and reversibility of collateral formation (in peripheral, splanchnic and pulmonary area), by treating mice with anti-PLGF and by using PLGF knock-out mice. Fibrosis formation and the role of hepatic stellate cells in the angiogenesis setting will be studied. In mice models of NASH will be the role of angiogenesis in fibrosis and colalteral formation studied in different ...
Treatment and prevention of thrombotic thrombocytopenic purpura in a unique animal model. KU Leuven
Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes and ABC drug transporters in a porcine animal model Ghent University
Mycotoxins are feed and food contaminants which can modulate the expression of genes encoding for CYP450 enzymes and ABC drug transporters and/or may modulate their activity. The goal of this research proposal is to investigate the effect of mycotoxin intake on the pharmacokinetic behavior of CYP450 and ABC substrate drugs in a pig animal model.